<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001807983</cik>
        <entityName>Medicenna Therapeutics Corp.</entityName>
        <issuerAddress>
            <street1>2 BLOOR ST W., 7TH FLOOR</street1>
            <city>TORONTO</city>
            <stateOrCountry>A6</stateOrCountry>
            <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
            <zipCode>M4W 3E2</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>416-648-5555</issuerPhoneNumber>
        <jurisdictionOfInc>CANADA (FEDERAL LEVEL)</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>A2 Acquisition Corp.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2015</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>FAHAR</firstName>
                <lastName>MERCHANT</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2 BLOOR ST W., 7TH FLOOR</street1>
                <city>TORONTO</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ELIZABETH</firstName>
                <lastName>WILLIAMS</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2 BLOOR ST W., 7TH FLOOR</street1>
                <city>TORONTO</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>CHANDRA</firstName>
                <lastName>PANCHAL</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2 BLOOR ST W., 7TH FLOOR</street1>
                <city>TORONTO</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ALBERT</firstName>
                <middleName>G.</middleName>
                <lastName>BERALDO</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2 BLOOR ST W., 7TH FLOOR</street1>
                <city>TORONTO</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>KAREN</firstName>
                <lastName>DAWES</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2 BLOOR ST W., 7TH FLOOR</street1>
                <city>TORONTO</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ROSEMINA</firstName>
                <lastName>MERCHANT</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2 BLOOR ST W., 7TH FLOOR</street1>
                <city>TORONTO</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ANDREW</firstName>
                <lastName>STRONG</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2 BLOOR ST W., 7TH FLOOR</street1>
                <city>TORONTO</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M4W 3E2</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001807983-20-000001</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2020-03-17</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>HAYWOOD SECURITIES (USA) INC.</recipientName>
                <recipientCRDNumber>849696</recipientCRDNumber>
                <associatedBDName>HAYWOOD SECURITIES INC.</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>200 BURRARD STREET</street1>
                    <street2>SUITE 700</street2>
                    <city>VANCOUVER</city>
                    <stateOrCountry>A1</stateOrCountry>
                    <stateOrCountryDescription>BRITISH COLUMBIA, CANADA</stateOrCountryDescription>
                    <zipCode>V6C 3L6</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>PA</state>
                    <description>PENNSYLVANIA</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>MACKIE RESEARCH USA INC.</recipientName>
                <recipientCRDNumber>39670</recipientCRDNumber>
                <associatedBDName>MACKIE RESEARCH CAPITAL CORPORATION</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>199 BAY STREET, SUITE 4500</street1>
                    <street2>COMMERCE COURT WEST</street2>
                    <city>TORONTO</city>
                    <stateOrCountry>A6</stateOrCountry>
                    <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                    <zipCode>M5L 1G2</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>PA</state>
                    <description>PENNSYLVANIA</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>9219339</totalOfferingAmount>
            <totalAmountSold>9219339</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>U.S. dollar amounts based on the Bank of Canada average rate of exchange reported on March 17, 2020, which was Cdn$1.4175=US$1.00.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>6</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </findersFees>
            <clarificationOfResponse>The Company has granted a 30-day over-allotment option to sell up to an additional 15% of the number of shares sold as part of the offering.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>In the ordinary course of business, the issuer may use some of the proceeds of the offering to pay salaries to certain of its executive officers and directors.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Medicenna Therapeutics Corp.</issuerName>
                <signatureName>ELIZABETH WILLIAMS</signatureName>
                <nameOfSigner>ELIZABETH WILLIAMS</nameOfSigner>
                <signatureTitle>CHIEF FINANCIAL OFFICER</signatureTitle>
                <signatureDate>2020-04-20</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
