X0306 4/A 2021-02-17 2021-02-19 0 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001807133 Ludwig Jeffrey Jerome C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BOULEVARD LOS ANGELES CA 90024 0 1 0 0 Chief Commercial Officer COMMON STOCK 2021-02-17 4 A 0 36069 0.00 A 36069 D Subject to the Grantee's continued service with the Company through the applicable vesting date, the Restricted Stock Units shall vest with respect to (i) one-third (1/3) of the Restricted Stock Units on the first anniversary of the vesting commencement date of January 1, 2021 (the "Vesting Commencement Date") and (ii) one-sixth (1/6th) of the Restricted Stock Units on each of July 1, 2022, January 1, 2023, July 1, 2023 and January 1, 2024. This amended Form 4 is filed solely to correct a typo relating to the vesting schedule of the Restricted Stock Units in the initial filing. /s/ Jeffrey Jerome Ludwig 2021-02-23