X0306 4 2022-06-15 0 0001807120 Design Therapeutics, Inc. DSGN 0001728741 Xu Stella C/O DESIGN THERAPEUTICS, INC. 6005 HIDDEN VALLEY ROAD, SUITE 110 CARLSBAD CA 92011 1 0 0 0 Stock Option (right to buy) 13.69 2022-06-15 4 A 0 15000 0.00 A 2032-06-14 Common Stock 15000 15000 D The shares subject to the option vest in equal monthly installments over 12 months following June 15, 2022 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders. /s/ Mustapha Parekh, Attorney-in-Fact 2022-06-16