X0206 3 2021-06-15 0 0001807120 Design Therapeutics, Inc. DSGN 0001867165 Prasad Deepa C/O DESIGN THERAPEUTICS, INC. 6005 HIDDEN VALLEY ROAD, SUITE 110 CARLSBAD CA 92011 1 0 0 0 Common Stock 1479946 I By WRG Healthcare Fund I, LP Common Stock 337327 I By WRG HCD1, LLC The reported securities are held directly by WRG Healthcare Fund I, LP. The reporting person is a member of the investment committee of WRG Healthcare Fund I, LP and may be deemed to have power to vote or dispose of these shares. The reporting person disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein. The reported securities are held directly by WRG HCD1, LLC. The reporting person is a member of WRG HCD1, LLC and may be deemed to have power to vote or dispose of these shares. The reporting person disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein. /s/ Mustapha Parekh, Attorney-in-Fact 2021-06-16