X0306 4 2021-03-30 0 0001807120 Design Therapeutics, Inc. DSGN 0001580787 Shah Pratik C/O DESIGN THERAPEUTICS, INC. 6005 HIDDEN VALLEY ROAD, SUITE 110 CARLSBAD CA 92011 1 1 0 0 Executive Chairperson Common Stock 2021-03-30 4 P 0 25000 20.00 A 25000 D Common Stock 2021-03-30 4 C 0 104923 A 129923 I By Pratik Shah Living Trust (6/15/2011) Series A Preferred Stock 2021-03-30 4 C 0 171025 0.00 D Common Stock 104923 0 I By Pratik Shah Living Trust (6/15/2011) The shares were purchased in the Issuer's initial public offering. All outstanding shares of Preferred Stock automatically converted into shares of Common Stock immediately upon the closing of the Issuer's initial public offering, for no additional consideration at a rate of one share of Common Stock for each 1.63 shares of Preferred Stock, based on the conversion price currently in effect. The Preferred Stock has no expiration date. The Reporting Person is the Trustee of the Pratik Shah Living Trust (6/15/2011). The Reporting Person disclaims beneficial ownership of these securities except to the extent of Reporting Person's pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. /s/ Mustapha Parekh, Attorney-in-Fact 2021-04-01