Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (94,879)	$ (106,476)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	11,028	17,439
Depreciation and amortization expense	6,576	9,925
Loss on property and equipment disposals, net	3,759	15
Net amortization and accretion on marketable securities	(2,890)	(8,129)
Change in fair value of contingent consideration payable	(2,075)	0
Non-cash lease income	(1,516)	(979)
Impairment of long-lived assets	1,443	0
Change in fair value of success payment liabilities	(240)	(566)
Loss (gain) on marketable equity security	28	(149)
Impairment of other investments	0	13,001
Changes in operating assets and liabilities:
Prepaid expenses, other current assets and other assets	4,796	(246)
Accounts payable	(1,885)	(630)
Accrued liabilities and other current liabilities	(13,118)	(3,090)
Other non-current liabilities	(223)	(225)
Net cash used in operating activities	(89,196)	(80,110)
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of property and equipment	(414)	(361)
Purchases of marketable securities	(165,112)	(224,475)
Maturities of marketable securities	247,639	291,837
Net cash provided by investing activities	82,113	67,001
CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from exercise of stock options	0	155
Proceeds from employee stock purchase plan	184	810
Taxes paid related to net share settlement of equity awards	0	(76)
Net cash provided by financing activities	184	889
Net decrease in cash, cash equivalents and restricted cash	(6,899)	(12,220)
Cash, cash equivalents and restricted cash at beginning of period	107,287	145,931
Cash, cash equivalents and restricted cash at end of period	100,388	133,711
Represented by:
Cash and cash equivalents	98,804	133,424
Restricted cash	1,584	287
Total	100,388	133,711
SUPPLEMENTAL CASH FLOW INFORMATION
Cash paid for amounts included in the measurement of lease liabilities	6,252	5,551
Non-cash investing and financing activities:
Purchases of property and equipment included in accounts payable and accrued liabilities	$ 9	$ 50