Income Taxes - Schedule of Deferred Tax Assets (Details) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Deferred tax assets:
Net operating loss carryforward	$ 242,841	$ 176,298
Tax credit carryforward	42,501	37,611
Capital loss carryforward	14,585	14,705
Accrued liabilities and allowances	3,070	3,818
Property and equipment	10,758	10,551
Intangibles capitalized for tax	30,107	5,582
Capitalized research and development	59,709	82,389
Investment basis difference	7,761	7,820
Lease liability	14,134	16,486
Stock-based compensation	7,893	10,036
Other	819	1,061
Gross deferred tax assets	434,178	366,357
Valuation allowance	(428,947)	(359,440)	$ (248,420)
Deferred tax assets, net of valuation allowance	5,231	6,917
Deferred tax liabilities:
Operating lease right-of-use assets	(5,231)	(6,917)
Deferred tax liabilities	(5,231)	(6,917)
Net deferred tax assets	$ 0	$ 0