License, Collaboration and Success Payment Agreements - Narrative (Details)		12 Months Ended
		Dec. 31, 2025 USD ($) $ / shares	Dec. 31, 2024 USD ($) $ / shares	Dec. 31, 2023 USD ($) $ / shares	Oct. 31, 2020 USD ($) $ / shares	Dec. 31, 2018 USD ($) $ / shares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Reduction in net loss		$ (274,448,000)	$ (342,994,000)	$ (234,632,000)
Reduction in net loss per common share, basic (in dollars per share) | $ / shares	[1]	$ (16.06)	$ (26.23)	$ (18.70)
Reduction in net loss per common share, diluted (in dollars per share) | $ / shares	[1]	$ (16.06)	$ (26.23)	$ (18.70)
Impairment of other investments		$ 0	$ 13,001,000	$ 12,923,000
Other Investment
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Impairment of other investments		0	13,000,000.0	12,900,000
Series A Convertible Preferred Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Convertible preferred stock, par value (in dollars per share) | $ / shares					$ 36.58	$ 36.58
Fred Hutch | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential aggregate success payments		0
Term of success payment agreement (in years)						9 years
Trigger period from IPO date (in years)						1 year
Trigger period thereafter (in years)						2 years
Fair value of potential success payments due		400,000	100,000
Success payment expense/(gain)		300,000	(500,000)	(1,900,000)
Fred Hutch | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance						10
Potential aggregate success payments						$ 10,000,000.0
Per share common stock price required for payment (in dollars per share) | $ / shares						$ 365.76
Fred Hutch | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance						50
Potential aggregate success payments						$ 200,000,000.0
Per share common stock price required for payment (in dollars per share) | $ / shares						$ 1,828.8
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential aggregate success payments		0
Term of success payment agreement (in years)					9 years
Trigger period from IPO date (in years)					1 year
Trigger period thereafter (in years)					2 years
Success payment expense/(gain)		500,000	(600,000)	(900,000)
Success payment liability		$ 800,000	$ 300,000
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance					10
Potential aggregate success payments					$ 10,000,000.0
Per share common stock price required for payment (in dollars per share) | $ / shares					$ 365.76
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance					50
Potential aggregate success payments					$ 200,000,000.0
Per share common stock price required for payment (in dollars per share) | $ / shares					$ 1,828.8
PACT | Other Investment
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Impairment of other investments				$ 2,900,000

[1] 1. Amounts previously reported have been retroactively adjusted to reflect the 1-for-20 reverse stock split effected on May 30, 2025. See Note 2.