Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2025

Share-Based Payment Arrangement [Abstract]

Schedule of Stock-based Compensation Expense by Classification

Stock-based compensation expense by classification included within the consolidated statements of operations and comprehensive loss was as follows (in thousands):

	Year Ended December 31,
	2025		2024		2023
Research and development	$	28,743	$	14,577	$	18,207
General and administrative	13,086		18,567		28,877
Total stock-based compensation expense	$	41,829	$	33,144	$	47,084

Schedule of PSU Activity

A summary of the Company’s PSU activity was as follows:

	Performance-Based Restricted Stock Units Outstanding	Weighted-Average Value at Grant Date Per Share
Unvested PSUs as of December 31, 2024	135,170	$	37.63
PSUs granted(1)	—	$	—
PSUs vested	(33,623)	$	36.00
PSUs forfeited or canceled	(36,029)	$	39.36
Unvested PSUs as of December 31, 2025	65,518	$	37.51

(1)     PSU grants reflect the target number of shares eligible to be earned at the time of grant.

Schedule of RSU Activity

A summary of the Company’s RSU activity was as follows:

	Restricted Stock Units Outstanding	Weighted-Average Value at Grant Date Per Share
Unvested RSUs as of December 31, 2024	281,190	$	34.40
RSUs granted	287,735	$	11.82
RSUs vested	(139,928)	$	25.66
RSUs forfeited or canceled	(122,582)	$	24.88
Unvested RSUs as of December 31, 2025	306,415	$	19.77

Schedule of Stock Option Activity

A summary of the Company’s PBO activity was as follows:

	Number of PBOs	Weighted-Average Exercise Price Per Share		Weighted- Average Remaining Contractual Life (in years)	Aggregate Intrinsic Value (in thousands)
PBOs outstanding as of December 31, 2024	—	$	—	—	$	—
Granted(1)	138,250	$	11.07
Exercised	—	$	—
Canceled or forfeited	(39,382)	$	11.07
PBOs outstanding as of December 31, 2025	98,868	$	11.07	9.11	$	1,949
PBOs exercisable as of December 31, 2025	—	$	—	—	$	—

(1)     PBO grants reflect the target number of shares eligible to be earned at the time of grant.

A summary of the Company’s stock option activity was as follows:

	Number of Stock Options	Weighted-Average Exercise Price Per Share		Weighted- Average Remaining Contractual Life (in years)	Aggregate Intrinsic Value (in thousands)
Options outstanding as of December 31, 2024	2,239,354	$	49.80	6.62	$	1,479
Granted	864,491	$	14.25
Exercised	(3,750)	$	11.07
Canceled or forfeited	(403,651)	$	36.96
Options outstanding as of December 31, 2025	2,696,444	$	40.32	6.14	$	17,090
Options exercisable as of December 31, 2025	1,660,556	$	52.51	4.40	$	4,704

Schedule of Assumptions Used in Black-Scholes Option-Pricing Model for Estimating Fair Value of Stock Options Granted

The fair value of stock options and performance-based stock options granted to employees, directors and consultants valued using the Black-Scholes option pricing model was estimated on the date of grant using the following weighted-average assumptions:

	Year Ended December 31,
	2025		2024		2023
Risk-free interest rate	4.05	%	4.17	%	4.13	%
Expected volatility	85.7	%	75.9	%	88.0	%
Expected term (in years)	6.04		5.89		6.06
Expected dividend yield	0	%	0	%	0	%