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Property and Equipment, Net
 12 Months Ended
Dec. 31, 2025
Property, Plant and Equipment [Abstract]  
Property and Equipment, Net Property and Equipment, Net
Property and equipment, net, consisted of the following (in thousands):
December 31,
2025
2024
Leasehold improvements
$
79,739 
$
79,613 
Laboratory equipment
26,372 
36,106 
Computer equipment and software
1,672 
1,805 
Furniture and fixtures
814 
1,114 
Construction in progress
452 
241 
Property and equipment, at cost
109,049 
118,879 
Less: Accumulated depreciation and amortization
(74,278)
(70,679)
Total property and equipment, net
$
34,771 
$
48,200 
Depreciation and amortization expense was $10.4 million, $19.4 million and $20.2 million for the years ended December 31, 2025, 2024 and 2023, respectively.
During the year ended December 31, 2024, the Company recorded impairment losses of $38.7 million for leasehold improvements. The Company did not record any impairment losses related to leasehold improvements in 2025 or 2023. See Note 5, Impairment of Long‑Lived Assets, for further information.