Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (60,667)	$ (66,959)
Adjustments to reconcile net loss to net cash used in operating activities:
Impairment of other investments	13,001	10,000
Stock-based compensation expense	9,155	13,882
Depreciation and amortization expense	5,024	5,027
Net amortization and accretion on marketable securities	(4,367)	(1,850)
Gain on marketable equity securities	(1,535)	0
Change in fair value of success payment liabilities	968	(1,708)
Non-cash lease income	(373)	(293)
Loss on property and equipment disposals, net	15	0
Changes in operating assets and liabilities:
Prepaid expenses, other current assets and other assets	595	(408)
Accounts payable	(113)	2,069
Accrued liabilities and other current liabilities	(3,606)	(5,860)
Other non-current liabilities	(113)	(112)
Net cash used in operating activities	(42,016)	(46,212)
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of property and equipment	(30)	(1,533)
Purchases of marketable securities	(108,011)	(108,560)
Maturities of marketable securities	130,035	142,247
Net cash provided by investing activities	21,994	32,154
CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from exercise of stock options	103	0
Taxes paid related to net share settlement of equity awards	(76)	(69)
Net cash provided by (used in) financing activities	27	(69)
Net decrease in cash, cash equivalents and restricted cash	(19,995)	(14,127)
Cash, cash equivalents and restricted cash at beginning of period	145,931	123,834
Cash, cash equivalents and restricted cash at end of period	125,936	109,707
Represented by:
Cash and cash equivalents	125,650	109,426
Restricted cash	286	281
Total	125,936	109,707
SUPPLEMENTAL CASH FLOW INFORMATION
Cash paid for amounts included in the measurement of lease liabilities	2,659	2,406
Non-cash investing and financing activities:
Purchases of property and equipment included in accounts payable and accrued liabilities	$ 220	$ 395