License, Collaboration, and Success Payment Agreements - Narrative (Details)		1 Months Ended		3 Months Ended			6 Months Ended
	Oct. 01, 2022 USD ($)	Jun. 30, 2020 USD ($) $ / shares shares	May 31, 2019 USD ($) $ / shares shares	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Dec. 31, 2021 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Dec. 31, 2022 USD ($)	Oct. 31, 2020 USD ($) $ / shares	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($) $ / shares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development expense				$ 47,471,000	$ 43,719,000		$ 92,101,000	$ 79,549,000
Impairment of other investments				2,923,000	0		12,923,000	0
Settled Litigation
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Ownership of fully diluted shares (as a percent)	80.00%
PACT
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Impairment of other investments						$ 36,400,000
Series A Convertible Preferred Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Convertible preferred stock, par value (in dollars per share) | $ / shares										$ 1.83		$ 1.83
Fred Hutch | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Annual license maintenance payments												$ 50,000
Aggregate research payments due												$ 12,000,000
Term of collaborative arrangement for research												6 years
Research and development expense				100,000	500,000		400,000	1,000,000
Aggregate success payment(s) (in millions)				0			0
Term of success payment agreement												9 years
Trigger period from IPO date												1 year
Trigger period thereafter												2 years
Fair value of potential success payments due				1,900,000			1,900,000		$ 2,500,000
Success payment expense (gain)				500,000	2,200,000		(600,000)	(600,000)
Fred Hutch | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance												10
Aggregate success payment(s) (in millions)												$ 10,000,000
Per share common stock price required for payment (in dollars per share) | $ / shares												$ 18.29
Fred Hutch | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance												50
Aggregate success payment(s) (in millions)												$ 200,000,000
Per share common stock price required for payment (in dollars per share) | $ / shares												$ 91.44
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Annual license maintenance payments											$ 50,000
Aggregate research payments due										$ 12,000,000
Term of collaborative arrangement for research										4 years
Research and development expense				700,000	800,000		1,500,000	1,500,000
Aggregate success payment(s) (in millions)				0			0
Term of success payment agreement										9 years
Trigger period from IPO date										1 year
Trigger period thereafter										2 years
Fair value of potential success payments due				2,700,000			2,700,000		3,300,000
Success payment expense (gain)				600,000	1,400,000		0	400,000
Success payment liability				1,900,000			1,900,000		1,900,000
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments due											2,500,000
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance										10
Aggregate success payment(s) (in millions)										$ 10,000,000
Per share common stock price required for payment (in dollars per share) | $ / shares										$ 18.29
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance										50
Aggregate success payment(s) (in millions)										$ 200,000,000
Per share common stock price required for payment (in dollars per share) | $ / shares										$ 91.44
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments due											$ 3,700,000
GSK | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Contract liabilities				0			0		0
Revenue recognized				0	35,700,000		0	36,300,000
GSK | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Adjustment To Revenue Related To Change In Estimate
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue recognized					$ 35,300,000			$ 35,300,000
GSK | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Contract liabilities			$ 45,000,000	0			0		0
Stock purchase agreement portion of transaction price			58,600,000
Transaction price			$ 103,600,000
Contract assets				$ 0			$ 0		$ 0
GSK | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | License | Series AA Convertible Preferred Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Stock sold under stock purchase program (in shares) | shares			30,253,189
Price per share of stock sold under stock purchase program (in dollars per share) | $ / shares			$ 6.78
Fair value per share of stock sold under stock purchase program (in dollars per share) | $ / shares			$ 4.84
PACT
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Gain on other investments	$ 2,900,000
PACT | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront payment		$ 50,000,000
Stock purchase agreement, stock purchased (in shares) | shares		17,806,901
Stock purchase agreement, purchase price per share (in dollars per share) | $ / shares		$ 2.81
Stock purchase agreement, fair value per share (in dollars per share) | $ / shares		$ 2.05
Additional purchase price consideration		$ 13,600,000
Total upfront payment paid		63,600,000
PACT | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Other Investment
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Strategic equity investment		$ 36,400,000