License, Collaboration, and Success Payment Agreements - Narrative (Details)		1 Months Ended		3 Months Ended
	Oct. 01, 2022 USD ($)	Jun. 30, 2020 USD ($) $ / shares shares	May 31, 2019 USD ($) $ / shares shares	Mar. 31, 2023 USD ($)	Mar. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2022 USD ($)	Oct. 31, 2020 USD ($) $ / shares	Dec. 31, 2019 USD ($)	Dec. 31, 2018 USD ($) $ / shares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development expense				$ 44,630,000	$ 35,830,000
Impairment of other investments				10,000,000	0
Settled Litigation
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Ownership of fully diluted shares (as a percent)	80.00%
PACT
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Impairment of other investments						$ 36,400,000
Series A Convertible Preferred Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Convertible preferred stock, par value (in dollars per share) | $ / shares								$ 1.83		$ 1.83
Fred Hutch | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Annual license maintenance payments										$ 50,000
Aggregate research payments due										$ 12,000,000
Term of collaborative arrangement for research										6 years
Research and development expense				300,000	500,000
Aggregate success payment(s) (in millions)				0
Term of success payment agreement										9 years
Trigger period from IPO date										1 year
Trigger period thereafter										2 years
Success payment expense (gain)				(1,100,000)	(2,800,000)
Fair value of potential success payments due				1,400,000			$ 2,500,000
Fred Hutch | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance										10
Aggregate success payment(s) (in millions)										$ 10,000,000
Per share common stock price required for payment (in dollars per share) | $ / shares										$ 18.29
Fred Hutch | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance										50
Aggregate success payment(s) (in millions)										$ 200,000,000
Per share common stock price required for payment (in dollars per share) | $ / shares										$ 91.44
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Annual license maintenance payments									$ 50,000
Aggregate research payments due								$ 12,000,000
Term of collaborative arrangement for research								4 years
Research and development expense				800,000	800,000
Aggregate success payment(s) (in millions)				0
Term of success payment agreement								9 years
Trigger period from IPO date								1 year
Trigger period thereafter								2 years
Success payment liability				1,200,000			1,900,000
Success payment expense (gain)				(600,000)	(1,000,000)
Fair value of potential success payments due				2,000,000			3,300,000
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments due									2,500,000
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance								10
Aggregate success payment(s) (in millions)								$ 10,000,000
Per share common stock price required for payment (in dollars per share) | $ / shares								$ 18.29
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance								50
Aggregate success payment(s) (in millions)								$ 200,000,000
Per share common stock price required for payment (in dollars per share) | $ / shares								$ 91.44
Stanford | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Maximum | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments due									$ 3,700,000
GSK | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Contract liabilities				0			0
Revenue recognized				0	$ 600,000
GSK | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Contract liabilities			$ 45,000,000	0			0
Stock purchase agreement portion of transaction price			58,600,000
Transaction price			$ 103,600,000
Contract assets				$ 0			$ 0
GSK | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | License | Series AA Convertible Preferred Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Stock sold under stock purchase program (in shares) | shares			30,253,189
Price per share of stock sold under stock purchase program (in dollars per share) | $ / shares			$ 6.78
Fair value per share of stock sold under stock purchase program (in dollars per share) | $ / shares			$ 4.84
PACT
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Gain on other investments	$ 2,900,000
PACT | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront payment		$ 50,000,000
Stock purchase agreement, stock purchased (in shares) | shares		17,806,901
Stock purchase agreement, purchase price per share (in dollars per share) | $ / shares		$ 2.81
Stock purchase agreement, fair value per share (in dollars per share) | $ / shares		$ 2.05
Additional purchase price consideration		$ 13,600,000
Total upfront payment paid		63,600,000
PACT | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Other Investment
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Strategic equity investment		$ 36,400,000