Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 109,426	$ 123,554
Marketable securities	503,343	516,598
Prepaid expenses and other current assets	11,629	11,143
Total current assets	624,398	651,295
Restricted cash	281	280
Marketable securities, non-current	55,255	70,117
Other investments	34,924	44,924
Property and equipment, net	118,600	123,023
Operating lease right-of-use assets	42,390	43,242
Other non-current assets	4,602	4,680
Total assets	880,450	937,561
Current liabilities:
Accounts payable	5,733	3,917
Accrued liabilities and other current liabilities	22,416	28,755
Success payment liabilities	2,648	4,356
Total current liabilities	30,797	37,028
Operating lease liabilities, non-current	61,826	63,168
Other non-current liabilities	4,001	4,113
Total liabilities	96,624	104,309
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.0001 par value; 10,000 shares authorized at March 31, 2023 and December 31, 2022; no shares issued and outstanding at March 31, 2023 and December 31, 2022	0	0
Common stock, $0.0001 par value; 500,000 shares authorized at March 31, 2023 and December 31, 2022; 249,609 and 249,567 shares issued and outstanding at March 31, 2023 and December 31, 2022, respectively	25	25
Additional paid-in capital	1,622,119	1,608,306
Accumulated other comprehensive loss	(3,879)	(7,599)
Accumulated deficit	(834,439)	(767,480)
Total stockholders’ equity	783,826	833,252
Total liabilities and stockholders’ equity	$ 880,450	$ 937,561