License, Collaboration and Success Payment Agreements - Aggregate Potential Success Payments (Details) - Collaborative Arrangement, Transaction with Party to Collaborative Arrangement	Dec. 31, 2022 USD ($)	Oct. 31, 2020 USD ($) $ / shares	Dec. 31, 2019	Dec. 31, 2018 USD ($) $ / shares
Fred Hutch
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate success payment(s) (in millions)	$ 0
Fred Hutch | Ten Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance			10
Per share common stock price required for payment (in dollars per share) | $ / shares				$ 18.29
Aggregate success payment(s) (in millions)				$ 10,000,000
Fred Hutch | Twenty Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance			20
Per share common stock price required for payment (in dollars per share) | $ / shares				$ 36.58
Aggregate success payment(s) (in millions)				$ 40,000,000
Fred Hutch | Thirty Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance			30
Per share common stock price required for payment (in dollars per share) | $ / shares				$ 54.86
Aggregate success payment(s) (in millions)				$ 90,000,000
Fred Hutch | Forty Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance			40
Per share common stock price required for payment (in dollars per share) | $ / shares				$ 73.15
Aggregate success payment(s) (in millions)				$ 140,000,000
Fred Hutch | Fifty Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance			50
Per share common stock price required for payment (in dollars per share) | $ / shares				$ 91.44
Aggregate success payment(s) (in millions)				$ 200,000,000
Stanford
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate success payment(s) (in millions)	$ 0
Stanford | Ten Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance		10
Per share common stock price required for payment (in dollars per share) | $ / shares		$ 18.29
Aggregate success payment(s) (in millions)		$ 10,000,000
Stanford | Twenty Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance		20
Per share common stock price required for payment (in dollars per share) | $ / shares		$ 36.58
Aggregate success payment(s) (in millions)		$ 40,000,000
Stanford | Thirty Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance		30
Per share common stock price required for payment (in dollars per share) | $ / shares		$ 54.86
Aggregate success payment(s) (in millions)		$ 90,000,000
Stanford | Forty Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance		40
Per share common stock price required for payment (in dollars per share) | $ / shares		$ 73.15
Aggregate success payment(s) (in millions)		$ 140,000,000
Stanford | Fifty Times
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Multiple of initial equity value at issuance		50
Per share common stock price required for payment (in dollars per share) | $ / shares		$ 91.44
Aggregate success payment(s) (in millions)		$ 200,000,000