Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Reconciliation of Federal Statutory Income Tax Rate

A reconciliation of income taxes computed using the U.S. federal statutory rate to that reflected in operations follows:

	Year Ended December 31,
	2022		2021		2020
Federal statutory tax	21.00	%	21.00	%	21.00	%
State tax, net of federal benefit	5.10		6.39		4.71
Valuation allowance	(28.89)		(22.43)		(24.60)
Collaboration revenue	6.72		—		—
Stock-based compensation	(6.11)		(5.92)		(1.77)
Tax credits	2.33		0.99		0.95
Other	(0.15)		(0.03)		(0.29)
Effective income tax rate	0.00	%	0.00	%	0.00	%

Schedule of Deferred Tax Assets

The principal components of the Company’s net deferred tax assets were as follows (in thousands):

	Year Ended December 31,
	2022		2021
Deferred tax assets:
Net operating loss carryforwards	$	106,530	$	70,855
Tax credit carryforwards	14,317		8,338
Accrued liabilities and allowances	3,692		3,879
Deferred revenue	904		8,224
Amortization	4,585		15,961
Capitalized research and development	26,199		—
Investment basis difference	14,235		13,587
Lease liability	17,656		18,429
Stock-based compensation	7,471		2,872
Other	1,171		2,613
Gross deferred tax assets	196,760		144,758
Valuation allowance	(180,132)		(127,226)
Deferred tax assets, net of valuation allowance	16,628		17,532
Deferred tax liabilities:
Operating lease right-of-use assets	(11,277)		(12,647)
Property and equipment	(5,351)		(4,885)
Deferred tax liabilities	(16,628)		(17,532)
Net deferred tax assets	$	—	$	—

Summary of Changes to Company’s Unrecognized Tax Benefits

The following table summarized changes to the Company’s unrecognized tax benefits (in thousands):

	Year Ended December 31,
	2022		2021
Beginning balance	$	796	$	—
Additions based on tax position related to the current year	—		396
Adjustments based on prior year tax positions	(396)		400
Ending balance	$	400	$	796