Consolidated Balance Sheets - USD ($) $ in Thousands		Dec. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents		$ 123,554	$ 293,828
Marketable securities		516,598	320,966
Prepaid expenses and other current assets		11,143	11,492
Total current assets		651,295	626,286
Restricted cash		280	466
Marketable securities, non-current		70,117	283,531
Other investments		44,924	47,001
Property and equipment, net		123,023	120,098
Operating lease right-of-use assets		43,242	46,541
Other non-current assets		4,680	3,483
Total assets		937,561	1,127,406
Current liabilities:
Accounts payable		3,917	3,207
Accrued liabilities and other current liabilities		28,755	29,057
Success payment liabilities		4,356	9,486
Deferred revenue	[1]	0	4,988
Total current liabilities		37,028	46,738
Operating lease liabilities, non-current		63,168	66,650
Deferred revenue, non-current	[2]	0	79,665
Other non-current liabilities		4,113	4,566
Total liabilities		104,309	197,619
Commitments and contingencies (Note 16)
Stockholders’ equity:
Preferred stock, $0.0001 par value; 10,000 shares authorized at December 31, 2022 and 2021, respectively; zero shares issued and outstanding at December 31, 2022 and 2021		0	0
Common stock, $0.0001 par value; 500,000 shares authorized at December 31, 2022 and 2021, respectively; 249,567 and 242,738 shares issued and outstanding at December 31, 2022 and 2021, respectively		25	24
Additional paid-in capital		1,608,306	1,515,748
Accumulated other comprehensive loss		(7,599)	(1,623)
Accumulated deficit		(767,480)	(584,362)
Total stockholders’ equity		833,252	929,787
Total liabilities and stockholders’ equity		$ 937,561	$ 1,127,406

[1] Includes amounts from a related-party of zero and $4,988 as of December 31, 2022 and December 31, 2021, respectively.

[2] Includes amounts from a related-party of zero and $79,665 as of December 31, 2022 and December 31, 2021, respectively.