Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (174,721)	$ (166,513)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	63,561	41,023
Depreciation and amortization expense	12,979	9,059
Impairment of other investments	5,000	0
Change in fair value of success payment liabilities	2,177	19,343
Change in fair value of equity warrant	1,067	199
Non-cash lease expense	(1,104)	1,486
Net amortization and accretion on marketable securities	278	1,434
Loss on property and equipment disposals, net	97	536
Changes in operating assets and liabilities:
Prepaid expenses, other current assets and other assets	(672)	(6,811)
Accounts payable	1,193	(8)
Accrued liabilities and other current liabilities	(5,836)	325
Deferred revenue	(36,299)	(7,697)
Operating lease liabilities, non-current	3,331	10,467
Other non-current liabilities	(339)	4,121
Net cash used in operating activities	(129,288)	(93,036)
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of property and equipment	(19,694)	(55,236)
Purchases of marketable securities	(346,647)	(539,541)
Sales and maturities of marketable securities	308,153	547,066
Net cash used in investing activities	(58,188)	(47,711)
CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from exercise of stock options	9,252	2,043
Proceeds from employee stock purchase plan	887	0
Taxes paid related to net share settlement of equity awards	(367)	0
Proceeds from initial public offering, net of issuance costs	0	391,802
Net cash provided by financing activities	9,772	393,845
Net (decrease) increase in cash, cash equivalents and restricted cash	(177,704)	253,098
Cash, cash equivalents and restricted cash at beginning of period	294,294	140,872
Cash, cash equivalents and restricted cash at end of period	116,590	393,970
Represented by:
Cash and cash equivalents	116,311	393,504
Restricted cash	279	466
Total	116,590	393,970
SUPPLEMENTAL CASH FLOW INFORMATION
Cash received for amounts related to tenant improvement allowances	3,238	11,063
Cash paid for amounts included in the measurement of lease liabilities	8,136	5,658
Non-cash investing and financing activities:
Purchases of property and equipment included in accounts payable and accrued liabilities	3,563	5,432
Remeasurement of operating lease right-of-use asset for lease modification	29	4,078
Conversion of convertible preferred stock to common stock upon closing of initial public offering	$ 0	$ 1,010,968