The amount by which the fair value of an investment is less than the amortized cost basis or carrying amount of that investment at the balance sheet date and the decline in fair value is deemed to be other than temporary, before considering whether or not such amount is recognized in earnings or other comprehensive income.

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Other Investments (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
Other Investments (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Sep. 30, 2021	Nov. 30, 2020
Schedule of Investments [Line Items]
Other investments	$ 47,001	$ 47,001	$ 83,448
Impairment of other investments		36,447	0	$ 0
PACT
Schedule of Investments [Line Items]
Other investments					$ 36,400
Impairment of other investments	36,400
Outpace Bio Inc \| Variable Interest Entity, Not Primary Beneficiary
Schedule of Investments [Line Items]
Noncontrolling interest in variable interest entity	$ 13,000	$ 13,000	$ 13,000			$ 13,000