Collaboration, License and Success Payment Agreements - Changes in Deferred Revenue (Details) - Collaborative Arrangement, Transaction with Party to Collaborative Arrangement - GSK $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($)
Contract With Customer, Liability [Roll Forward]
Deferred revenue balance at December 31, 2020	$ 95,161
Revenue recognized during the period previously recorded in deferred revenue	(10,508)
Deferred revenue balance at December 31, 2021	$ 84,653