Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 293,828	$ 140,406
Marketable securities	320,966	472,213
Prepaid expenses and other current assets	11,492	4,928
Total current assets	626,286	617,547
Restricted cash	466	466
Marketable securities, non-current	283,531	79,995
Other investments	47,001	83,448
Property and equipment, net	120,098	77,045
Operating lease right-of-use assets	46,541	47,010
Other non-current assets	3,483	2,769
Total assets	1,127,406	908,280
Current liabilities:
Accounts payable	3,207	9,396
Accrued liabilities and other current liabilities	29,057	28,021
Success payment liabilities	9,486	5,773
Deferred revenue	4,988	6,095
Total current liabilities	46,738	49,285
Operating lease liabilities, non-current	66,650	50,957
Deferred revenue, non-current	79,665	89,066
Other non-current liabilities	4,566	532
Total liabilities	197,619	189,840
Commitments and contingencies (Note 16)
Convertible preferred stock, $0.0001 par value; zero and 195,021 shares authorized at December 31, 2021 and 2020, respectively; zero and 194,474 shares issued and outstanding at December 31, 2021 and 2020, respectively	0	1,010,968
Stockholders’ equity (deficit):
Preferred stock, $0.0001 par value; 10,000 and zero shares authorized at December 31, 2021 and 2020, respectively; zero shares issued and outstanding at December 31, 2021 and 2020	0	0
Common stock, $0.0001 par value; 500,000 and 264,905 shares authorized at December 31, 2021 and 2020, respectively; 242,738 and 15,570 shares issued and outstanding at December 31, 2021 and 2020, respectively	24	2
Additional paid-in capital	1,515,748	41,357
Accumulated other comprehensive (loss) income	(1,623)	256
Accumulated deficit	(584,362)	(334,143)
Total stockholders’ equity (deficit)	929,787	(292,528)
Total liabilities, convertible preferred stock and stockholders’ equity (deficit)	$ 1,127,406	$ 908,280