X0306 4 2021-06-21 0 0001806952 Lyell Immunopharma, Inc. LYEL 0001411874 FRIEDMAN CATHY C/O LYELL IMMUNOPHARMA, INC. 400 EAST JAMIE COURT, SUITE 301 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2021-06-21 4 C 0 3765842 A 3765842 I Lyell Investors, LLC Common Stock 2021-06-21 4 P 0 17648 17.00 A 17648 I MSL FBO J DUANE & C FRIEDMAN TTEE DUANE FAMILY TRUST Common Stock 100000 I The Duane Irrevocable Trust 2020 Series A Convertible Preferred Stock 2021-06-21 4 C 0 3765842 D Common Stock 3765842 0 I Lyell Investors, LLC The Issuer's Series A Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date. The Reporting Person is a member of Lyell Investors, LLC and therefore may be deemed to share the power to direct the disposition and vote of the shares held by Lyell Investors, LLC. The Reporting Person disclaims beneficial ownership of all shares held by Lyell Investors, LLC except to any pecuniary interest therein. The Reporting Person is a trustee of MSL FBO J DUANE & C FRIEDMAN TTEE DUANE FAMILY TRUST ("Duane Family Trust") and therefore may be deemed to share the power to direct the disposition and vote of the shares held by the Duane Family Trust. The Reporting Person disclaims beneficial ownership of all shares held by Duane Family Trust except to any pecuniary interest therein. The Reporting Person is a trustee of The Duane Irrevocable Trust 2020 ("Duane Irrevocable Trust") and therefore may be deemed to share the power to direct the disposition and vote of the shares held by the Duane Irrevocable Trust. The Reporting Person disclaims beneficial ownership of all shares held by Duane Irrevocable Trust except to any pecuniary interest therein. /s/ Heather Turner, as Attorney-in-fact 2021-06-23