X0206 3 2021-06-16 0 0001806952 Lyell Immunopharma, Inc. LYEL 0001411874 FRIEDMAN CATHY C/O LYELL IMMUNOPHARMA, INC. 400 EAST JAMIE COURT, SUITE 301 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 100000 I The Duane Irrevocable Trust 2020 Series A Convertible Preferred Stock 1.8288 Common Stock 3765842 I Lyell Investors, LLC Option (right to buy) 5.81 2030-05-18 Common Stock 400000 D Option (right to buy) 5.96 2030-12-16 Common Stock 250000 D 1/4 of the shares vested on August 1, 2019, with the remaining shares to vest in equal monthly installments over the following thirty-six months. The Reporting Person is a trustee of The Duane Irrevocable Trust 2020 ("Duane Trust") and therefore may be deemed to share the power to direct the disposition and vote of the shares held by the Duane Trust. The Reporting Person disclaims beneficial ownership of all shares held by Duane Trust except to any pecuniary interest therein. The Series A Convertible Preferred Stock is convertible at any time, at the Reporting Person's election, has no expiration date, and will automatically convert to shares of the Issuer's Common Stock immediately prior to the closing of the Issuer's initial public offering on a 1-for-1 basis. The Reporting Person is a member of Lyell Investors, LLC and therefore may be deemed to share the power to direct the disposition and vote of the shares held by Lyell Investors, LLC. The Reporting Person disclaims beneficial ownership of all shares held by Lyell Investors, LLC except to any pecuniary interest therein. The shares vest in equal monthly installments over the thirty-six months following August 8, 2018. The option provides for an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase. The shares vest in equal monthly installments over the thirty-six months following January 1, 2021. The option provides for an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase /s/ Heather D. Turner, as Attorney-in-fact 2021-06-16