LYELL IMMUNOPHARMA, INC.

201 Haskins Way

South San Francisco, California 94080

VIA EDGAR

August 13, 2025

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attn: Joshua Gorsky

Re: Lyell Immunopharma, Inc

Registration Statement on Form S-3

File No. 333-289539

Acceleration Request
Requested Date:	August 15, 2025
Requested Time:	4:30 p.m. Eastern Time

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, Lyell Immunopharma, Inc. hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-289539) (the “Registration Statement”) to become effective on Friday, August 15, 2025, at 4:30 p.m. Eastern Time, or as soon thereafter as is practicable.

Once the Registration Statement has been declared effective, please orally confirm that event with Kenneth Guernsey or Asa M. Henin of Cooley LLP at (415) 693-2091 or (858) 550-6104. Thank you for your assistance with this matter.

Sincerely,
LYELL IMMUNOPHARMA, INC.
By:	/s/ Mark Meltz
	Mark Meltz
	General Counsel and Corporate Secretary