144 0001665124 XXXXXXXX LIVE 0001806310 Taysha Gene Therapies, Inc. 001-39536 3000 PEGASUS PARK DRIVE SUITE 1430 DALLAS TX 75247 (214) 612-0000 Nagendran Sukumar Officer Common Jefferies LLC

520 Madison Avenue 4th Floor New York NY 10022

200000 926000.00 287000000 04/10/2026 Nasdaq Common 01/02/2024 RSU Grant Taysha Gene Therapies, Inc. N 131550 01/02/2024 N/A Common 01/02/2025 RSU Grant Taysha Gene Therapies, Inc. N 49429 01/02/2025 N/A Common 01/02/2024 Stock Option Grant Taysha Gene Therapies, Inc N 19021 01/02/2024 N/A N Sukumar Nagendran

3000 PEGASUS PARK DRIVE SUITE 1430 DALLAS TX 75247

Common 01/12/2026 200000 942740.00 All Sales are to be made pursuant to a previously signed/adopted 10b5-1 Selling plan dated 6/11/2025 and all representations regarding material non-public information were made as of the adoption of the plan. 04/10/2026 06/11/2025 Sukumar Nagendran