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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flows from operating activities    
Net loss $ (50,111) $ (32,024)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation expense 257 32
Research and development license expense 1,250 5,500
Stock-based compensation 5,329 3,594
Other 194  
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 271 (4,184)
Accounts payable 2,544 1,872
Accrued expenses and other liabilities (538) 3,183
Due to related party   (8)
Net cash used in operating activities (40,804) (22,035)
Cash flows from investing activities    
Purchase of research and development license (3,000)  
Purchase of property, plant and equipment (8,427) (534)
Net cash used in investing activities (11,427) (534)
Cash flows from financing activities    
Payment of shelf registration costs (151)  
ESPP contributions 277  
Other (368)  
Net cash used in financing activities (242)  
Net decrease in cash, cash equivalents and restricted cash (52,473) (22,569)
Cash, cash equivalents and restricted cash at the beginning of the period 151,740 251,253
Cash, cash equivalents and restricted cash at the end of the period 99,267 228,684
Cash and cash equivalents 96,630 228,684
Restricted cash 2,637  
Supplemental disclosure of cash flow information:    
Cash paid for interest 419  
Supplemental disclosure of noncash investing and financing activities:    
Property, plant and equipment in accounts payable and accrued expenses 4,513 1,101
Acquisition of property, plant and equipment funded by landlord   607
Deferred offering costs not yet paid 21 128
Purchase of research and development license not yet paid $ 1,250 $ 5,500