Stock-Based Compensation - Schedule of Stock Option Activity (Details) - Stock Options - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2022	Dec. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Outstanding. Stock Options, Beginning Balance	3,649,962
Options granted, Stock Options	1,902,100
Options cancelled or forfeited, Stock Options	(109,405)
Options expired, Stock Options	(4,820)
Outstanding. Stock Options, Ending Balance	5,437,837	3,649,962
Options to be forfeited due to severance, Stock Options	(713,540)
Vested and expected to vest at March 31, 2022, Stock Options	4,724,297
Options exercisable at March 31, 2022, Stock Options	725,824
Outstanding, Weighted Average Exercise Price, Beginning balance	$ 24.13
Options granted, Weighted Average Exercise Price	6.31
Options cancelled or forfeited, Weighted Average Exercise Price	18.29
Options expired, Weighted Average Exercise Price	19.96
Outstanding, Weighted Average Exercise Price, Ending balance	18.02	$ 24.13
Options to be forfeited due to severance, Stock Options	16.37
Options exercisable at March 31, 2022, Weighted Average Exercise Price	$ 25.42
Outstanding, Weighted Average Remaining Contractual Life	9 years 3 months 18 days	9 years 2 months 12 days
Options exercisable at March 31, 2022, Weighted Average Remaining Contractual Life	8 years 8 months 12 days
Outstanding, Aggregate Intrinsic Value, Ending Balance	$ 976