Subsequent Events - Additional Information (Details) - Subsequent Event	1 Months Ended	3 Months Ended
	Mar. 31, 2022 USD ($)	Mar. 31, 2022 USD ($) $ / shares shares
Subsequent Event [Line Items]
Percentage of headcount reduced	35.00%
Severance and termination-related costs		$ 1,400,000
Options granted for purchase an aggregate share of common stock | shares		1,874,100
Weighted-average exercise price | $ / shares		$ 6.23
License Agreement for CLN7
Subsequent Event [Line Items]
Payment of one-time upfront license fee	$ 300,000
License agreement regulatory related milestones maximum amount payable	7,700,000	$ 7,700,000
License agreement sales-related milestones maximum amount payable	$ 7,500,000	$ 7,500,000