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<div id="toc94391_27" style="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold">Policies and Practices Related to the Grant of Certain Equity Awards Close in Time to the Release of Material Nonpublic Information </div><div style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">From time to time, the Company grants stock options or other stock awards to its employees, including the Named Executive Officers. Historically, the Company has granted <div style="white-space:nowrap;display:inline;">new-hire</div> option awards on or soon after a new hire’s employment start date and annual refresh employee option grants in the first quarter of each fiscal year, </div><div style="margin-top:0pt;margin-bottom:0pt ; font-size:8pt"> </div><div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:center"> </div><div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">which refresh grants are typically approved at the regularly scheduled meeting of the Compensation Committee occurring in such quarter or the immediately preceding quarter. Also, <div style="white-space:nowrap;display:inline;">non-employee</div> directors receive automatic grants of initial and annual stock option awards in addition to restricted stock unit awards, at the time of a director’s initial appointment or election to our Board of Directors and at the time of each annual meeting of the Company’s stockholders, respectively, pursuant to the <div style="white-space:nowrap;display:inline;">Non-Employee</div> Director Compensation Policy, as further described under the heading, <div style="white-space:nowrap;display:inline;">“Non-Employee</div> Director <div style="white-space:nowrap;display:inline;"><div style="white-space:nowrap;display:inline;">Compensation-Non-Employee</div></div> Director Compensation Policy” below. The Company does not otherwise maintain any written policies on the timing of awards of stock options, stock appreciation rights or similar instruments with option-like features. The Compensation Committee considers whether there is any material nonpublic information (“MNPI”) about the Company when determining the timing of awards of stock option, stock appreciation rights or similar instruments and does not seek to time the award of stock options, stock appreciation rights or similar instruments in relation to the Company’s public disclosure of MNPI. The Company has not timed the release of MNPI for the purpose of affecting the value of executive compensation. </div><div style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">During fiscal year 2025, we did not grant option awards to our Named Executive Officers during the period beginning four business days prior to and ended one business day following the filing of our periodic reports on <div style="white-space:nowrap;display:inline;">Form 10-Q</div> or <div style="white-space:nowrap;display:inline;">Form 10-K</div> or the filing or furnishing of a current report on <div style="white-space:nowrap;display:inline;">Form 8-K</div> that disclosed material <div style="white-space:nowrap;display:inline;">non-public</div> information. </div><div style="margin-top:0pt;margin-bottom:0pt ; font-size:8pt"> </div>
From time to time, the Company grants stock options or other stock awards to its employees, including the Named Executive Officers. Historically, the Company has granted <div style="white-space:nowrap;display:inline;">new-hire</div> option awards on or soon after a new hire’s employment start date and annual refresh employee option grants in the first quarter of each fiscal year,which refresh grants are typically approved at the regularly scheduled meeting of the Compensation Committee occurring in such quarter or the immediately preceding quarter.
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<div id="toc94391_28" style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold">Pay Versus Performance </div><div style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officer (“PEO”) and <div style="white-space:nowrap;display:inline;">Non-PEO</div> named executive officers <div style="white-space:nowrap;display:inline;">(“Non-PEO</div> NEOs”) and Company performance for the fiscal years listed below. The Compensation Committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the years shown. </div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:25%"></td>
<td style="vertical-align:bottom;width:3%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:3%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:3%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:3%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:3%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:3%"></td>
<td></td>
<td></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Year<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(1)</div></div></td>
<td style="vertical-align:bottom"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Summary<br/> Compensation<br/> Table Total for<br/> PEO<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(2)</div></div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Compensation<br/> Actually Paid to<br/> PEO<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(2), (3)</div></div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Summary<br/> Compensation<br/> Table Total for<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div><br/> NEOs<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(2)</div></div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Compensation<br/> Actually Paid to<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div> <div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(2), (3)</div></div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Value of Initial<br/> Fixed $100<br/> Investment<br/> based on:<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(4)</div></div><br/> <div style="font-weight:bold;display:inline;">TSR<br/> ($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Net Income<br/> (Loss)<br/> ($ Thousands)</div></td>
<td style="vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">4,099,065</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">18,260,853</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">2,119,927</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">9,424,103</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">310.73</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">(108,995</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">4,727,861</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">4,668,493</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">3,060,218</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">3,030,722</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">97.74</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">(89,298</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr></table><div style="line-height:8.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000;width:11%"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">1.</td>
<td style="vertical-align:top;text-align:left"><div style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">We are a smaller reporting company pursuant to Rule 405 of the Securities Act of 1933, and as such, we are only required to include information for the past two fiscal years for this first filing in which we are required to provide this disclosure. </div></td></tr></table>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">2.</td>
<td style="vertical-align:top;text-align:left"><div style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">Sean Nolan was our PEO for each year presented. The individuals comprising the <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs for each year presented are Kamran Alam and Sukumar Nagendran, M.D. </div></td></tr></table>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">3.</td>
<td style="vertical-align:top;text-align:left"><div style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation <div style="white-space:nowrap;display:inline;">S-K</div> and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total and the exclusions and inclusions of certain amounts for the PEO and the <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table. </div></td></tr></table> <div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:25%"></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Year</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Summary<br/> Compensation Table<br/> Total for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Exclusion of Stock<br/> Awards and Option<br/> Awards for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Inclusion of Equity<br/> Values for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Compensation Actually<br/> Paid to PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">4,099,065</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(2,909,550)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">17,071,338</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">18,260,853</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">4,727,861</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(3,696,226)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,636,858</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">4,668,493</td></tr></table><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:27%"></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Year</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average Summary<br/> Compensation Table<br/> Total for <div style="white-space:nowrap;display:inline;">Non-PEO</div><br/> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average Exclusion of<br/> Stock Awards and<br/> Option Awards for<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average Inclusion of<br/> Equity Values for<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average Compensation<br/> Actually Paid to<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">2,119,927</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(1,231,465)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">8,535,641</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">9,424,103</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,060,218</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(2,268,277)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">2,238,781</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,030,722</td></tr></table><div style="margin-top:0pt;margin-bottom:0pt ; font-size:8pt"> </div><div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:center"> </div><div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables: </div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:23%"></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Year</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;"><div style="white-space:nowrap;display:inline;">Year-End</div><br/> Fair Value of<br/> Equity<br/> Awards<br/> Granted<br/> During Year<br/> That<br/> Remained<br/> Unvested as<br/> of Last Day of<br/> Year for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Change in<br/> Fair Value<br/> from Last<br/> Day of Prior<br/> Year to Last<br/> Day of Year<br/> of Unvested<br/> Equity<br/> Awards for<br/> PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Vesting-<br/> Date Fair<br/> Value of<br/> Equity<br/> Awards<br/> Granted<br/> During<br/> Year that<br/> Vested<br/> During<br/> Year for<br/> PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Change in<br/> Fair Value<br/> from Last<br/> Day of Prior<br/> Year to<br/> Vesting Date<br/> of Unvested<br/> Equity<br/> Awards that<br/> Vested<br/> During Year<br/> for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Fair Value<br/> at Last Day<br/> of Prior<br/> Year of<br/> Equity<br/> Awards<br/> Forfeited<br/> During Year<br/> for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Total -</div><br/> <div style="font-weight:bold;display:inline;">Inclusion of</div><br/> <div style="font-weight:bold;display:inline;">Equity Values<br/> for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">9,099,878</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">6,883,035</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">1,088,425</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">17,071,338</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,548,347</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(12,917)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">101,428</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,636,858</td></tr></table><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:20%"></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Year</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> <div style="white-space:nowrap;display:inline;">Year-End</div><br/> Fair Value of<br/> Equity<br/> Awards<br/> Granted<br/> During Year<br/> That<br/> Remained<br/> Unvested as<br/> of Last Day of<br/> Year for Non-<br/> PEO NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Change in<br/> Fair Value<br/> from Last<br/> Day of Prior<br/> Year to Last<br/> Day of Year<br/> of Unvested<br/> Equity<br/> Awards for<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div><br/> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Vesting-<br/> Date Fair<br/> Value of<br/> Equity<br/> Awards<br/> Granted<br/> During<br/> Year that<br/> Vested<br/> During<br/> Year for<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div><br/> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Change in<br/> Fair Value<br/> from Last<br/> Day of Prior<br/> Year to<br/> Vesting Date<br/> of Unvested<br/> Equity<br/> Awards that<br/> Vested<br/> During Year<br/> for <div style="white-space:nowrap;display:inline;">Non-</div><br/> PEO NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Fair Value<br/> at Last Day<br/> of Prior<br/> Year of<br/> Equity<br/> Awards<br/> Forfeited<br/> During Year<br/> for <div style="white-space:nowrap;display:inline;">Non-</div></div><br/> <div style="font-weight:bold;display:inline;">PEO NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Total -<br/> Average<br/> Inclusion of</div><br/> <div style="font-weight:bold;display:inline;">Equity<br/> Values for <div style="white-space:nowrap;display:inline;">Non-</div><br/> PEO NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,851,517</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">4,077,753</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">606,371</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">8,535,641</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">2,177,536</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(7,807)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">69,052</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">2,238,781</td></tr></table><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">4.</td>
<td style="vertical-align:top;text-align:left"><div style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">The Total Shareholder Return (“TSR”) assumes $100 was invested in the Company for the period starting December 31, 2023, through the end of the listed year. Historical stock performance is not necessarily indicative of future stock performance. </div></td></tr></table>
4099065
18260853
2119927
9424103
310.73
-108995000
4727861
4668493
3060218
3030722
97.74
-89298000
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">2.</td>
<td style="vertical-align:top;text-align:left"><div style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">Sean Nolan was our PEO for each year presented. The individuals comprising the <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs for each year presented are Kamran Alam and Sukumar Nagendran, M.D. </div></td></tr></table>
Sean Nolan
Sean Nolan
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">3.</td>
<td style="vertical-align:top;text-align:left"><div style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation <div style="white-space:nowrap;display:inline;">S-K</div> and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total and the exclusions and inclusions of certain amounts for the PEO and the <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table. </div></td></tr></table>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:27%"></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Year</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average Summary<br/> Compensation Table<br/> Total for <div style="white-space:nowrap;display:inline;">Non-PEO</div><br/> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average Exclusion of<br/> Stock Awards and<br/> Option Awards for<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average Inclusion of<br/> Equity Values for<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average Compensation<br/> Actually Paid to<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">2,119,927</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(1,231,465)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">8,535,641</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">9,424,103</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,060,218</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(2,268,277)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">2,238,781</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,030,722</td></tr></table><div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables: </div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:20%"></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td>
<td style="vertical-align:bottom;width:6%"></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Year</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> <div style="white-space:nowrap;display:inline;">Year-End</div><br/> Fair Value of<br/> Equity<br/> Awards<br/> Granted<br/> During Year<br/> That<br/> Remained<br/> Unvested as<br/> of Last Day of<br/> Year for Non-<br/> PEO NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Change in<br/> Fair Value<br/> from Last<br/> Day of Prior<br/> Year to Last<br/> Day of Year<br/> of Unvested<br/> Equity<br/> Awards for<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div><br/> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Vesting-<br/> Date Fair<br/> Value of<br/> Equity<br/> Awards<br/> Granted<br/> During<br/> Year that<br/> Vested<br/> During<br/> Year for<br/> <div style="white-space:nowrap;display:inline;">Non-PEO</div><br/> NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Change in<br/> Fair Value<br/> from Last<br/> Day of Prior<br/> Year to<br/> Vesting Date<br/> of Unvested<br/> Equity<br/> Awards that<br/> Vested<br/> During Year<br/> for <div style="white-space:nowrap;display:inline;">Non-</div><br/> PEO NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Average<br/> Fair Value<br/> at Last Day<br/> of Prior<br/> Year of<br/> Equity<br/> Awards<br/> Forfeited<br/> During Year<br/> for <div style="white-space:nowrap;display:inline;">Non-</div></div><br/> <div style="font-weight:bold;display:inline;">PEO NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Total -<br/> Average<br/> Inclusion of</div><br/> <div style="font-weight:bold;display:inline;">Equity<br/> Values for <div style="white-space:nowrap;display:inline;">Non-</div><br/> PEO NEOs</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,851,517</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">4,077,753</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">606,371</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">8,535,641</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">2,177,536</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(7,807)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">69,052</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">2,238,781</td></tr></table>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">3.</td>
<td style="vertical-align:top;text-align:left"><div style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation <div style="white-space:nowrap;display:inline;">S-K</div> and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total and the exclusions and inclusions of certain amounts for the PEO and the <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table. </div></td></tr></table>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:25%"></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td>
<td style="vertical-align:bottom;width:9%"></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Year</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Summary<br/> Compensation Table<br/> Total for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Exclusion of Stock<br/> Awards and Option<br/> Awards for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Inclusion of Equity<br/> Values for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Compensation Actually<br/> Paid to PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">4,099,065</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(2,909,550)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">17,071,338</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">18,260,853</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">4,727,861</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(3,696,226)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,636,858</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">4,668,493</td></tr></table><div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables: </div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:23%"></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td>
<td style="vertical-align:bottom;width:5%"></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Year</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;"><div style="white-space:nowrap;display:inline;">Year-End</div><br/> Fair Value of<br/> Equity<br/> Awards<br/> Granted<br/> During Year<br/> That<br/> Remained<br/> Unvested as<br/> of Last Day of<br/> Year for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Change in<br/> Fair Value<br/> from Last<br/> Day of Prior<br/> Year to Last<br/> Day of Year<br/> of Unvested<br/> Equity<br/> Awards for<br/> PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Vesting-<br/> Date Fair<br/> Value of<br/> Equity<br/> Awards<br/> Granted<br/> During<br/> Year that<br/> Vested<br/> During<br/> Year for<br/> PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Change in<br/> Fair Value<br/> from Last<br/> Day of Prior<br/> Year to<br/> Vesting Date<br/> of Unvested<br/> Equity<br/> Awards that<br/> Vested<br/> During Year<br/> for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Fair Value<br/> at Last Day<br/> of Prior<br/> Year of<br/> Equity<br/> Awards<br/> Forfeited<br/> During Year<br/> for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td>
<td style="vertical-align:bottom"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="font-weight:bold;display:inline;">Total -</div><br/> <div style="font-weight:bold;display:inline;">Inclusion of</div><br/> <div style="font-weight:bold;display:inline;">Equity Values<br/> for PEO</div><br/> <div style="font-weight:bold;display:inline;">($)</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">9,099,878</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">6,883,035</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">1,088,425</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">17,071,338</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><div style=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman;text-align:center">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,548,347</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">(12,917)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">101,428</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">—</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">3,636,858</td></tr></table>
4099065
-2909550
17071338
18260853
4727861
-3696226
3636858
4668493
2119927
-1231465
8535641
9424103
3060218
-2268277
2238781
3030722
9099878
6883035
0
1088425
0
17071338
3548347
-12917
0
101428
0
3636858
3851517
4077753
0
606371
0
8535641
2177536
-7807
0
69052
0
2238781
<div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><div style="font-style:italic;display:inline;">Relationship Between PEO and <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEO Compensation Actually Paid and TSR </div></div><div style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs, and the cumulative TSR over the two most recently completed fiscal years for the Company. </div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div><div style="font-size:0pt;margin-top:0pt;margin-bottom:0pt"> </div><div style="margin-top:0pt;margin-bottom:0pt;text-align:center"></div><div style="margin-top:0pt;margin-bottom:0pt;text-align:center">
<img alt="LOGO" src="g94391g93e01.jpg" style="width:6.31538in;height:4.54728in"/> </div><div style="margin-top:0pt;margin-bottom:0pt ; font-size:8pt"> </div>
<div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><div style="font-style:italic;display:inline;">Relationship Between PEO and <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEO Compensation Actually Paid and Net Income (Loss) </div></div><div style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our <div style="white-space:nowrap;display:inline;">Non-PEO</div> NEOs, and our net income (loss) during the two most recently completed fiscal years. </div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div><div style="font-size:0pt;margin-top:0pt;margin-bottom:0pt"> </div><div style="margin-top:0pt;margin-bottom:0pt;text-align:center">
<img alt="LOGO" src="g94391g94e01.jpg" style="width:6.31589in;height:4.63358in"/> </div>