Astellas Agreements - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended	3 Months Ended
	Oct. 21, 2022	Oct. 31, 2022	Mar. 31, 2025	Mar. 31, 2024	Dec. 31, 2024
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Common stock, shares issued			205,054,570		204,943,306
Probability of option exercise		50.00%
Revenues			$ 2,302	$ 3,411
Deferred revenue			7,470		$ 9,773
Rett Option
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue			5,500		5,500
Rett research and development activities
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues			2,300	$ 3,400
Deferred revenue			2,000		$ 4,300
Astellas
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront Payment	$ 20,000
Transaction price		$ 36,100	36,059
Deferred revenue		$ 36,100
Astellas | Securities Purchase Agreement | Private Placement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Common stock, shares issued	7,266,342	7,266,342
Aggregate gross proceeds	$ 30,000
Fair value of shares transferred, Value		$ 13,950
Share price		$ 1.92
Transaction price		$ 16,100
Difference of market value paid		$ 30,000
Astellas | TSHA-120
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront Payment			20,000
Transaction price			36,100
Astellas | TSHA-120 | Private Placement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Transaction price			16,100
Astellas | Rett research and development activities
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Transaction price			$ 28,257