Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Cumulative Effect, Period of Adoption, Adjustment	Offering to Astellas	Public Offering	At-the-Market Offering	Private Placement	Common Stock	Common Stock Offering to Astellas	Common Stock Public Offering	Common Stock At-the-Market Offering	Common Stock Private Placement	Additional Paid-in Capital	Additional Paid-in Capital Offering to Astellas	Additional Paid-in Capital Public Offering	Additional Paid-in Capital At-the-Market Offering	Additional Paid-in Capital Private Placement	Accumulated Deficit	Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment
Balance at Dec. 31, 2021	$ 95,383	$ 222										$ 331,032					$ (235,649)	$ 222
Balance, shares at Dec. 31, 2021							38,473,945
Accounting Standards Update [Extensible Enumeration]	Accounting Standards Update 2016-02 [Member]
Stock-based compensation	$ 18,275											18,275
Issuance of common stock			$ 13,764	$ 27,457	$ 11,609					$ 1			$ 13,764	$ 27,457	$ 11,608
Issuance of common stock, shares								7,266,342	14,765,226	2,000,000
Issuance of common stock, upon vesting and settlement of restricted stock units, net, shares							628,921
Issuance of common stock under ESPP	253											253
Issuance of common stock under ESPP, shares							73,073
Net loss	(166,014)																(166,014)
Balance at Dec. 31, 2022	$ 949						$ 1					402,389					(401,441)
Balance, shares at Dec. 31, 2022	63,207,507						63,207,507
Stock-based compensation	$ 7,905											7,905
Issuance of common stock						$ 103,239					$ 1					$ 103,238
Issuance of common stock, shares											123,117,594
Issuance of common stock, upon vesting and settlement of restricted stock units, net, shares							566,772
Issuance of common stock under ESPP	68											68
Issuance of common stock under ESPP, shares							68,320
Reclassification of pre-funded warrants to equity classification	74,342											74,342
Net loss	(111,566)																(111,566)
Balance at Dec. 31, 2023	$ 74,937						$ 2					$ 587,942					$ (513,007)
Balance, shares at Dec. 31, 2023	186,960,193						186,960,193