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<ownershipDocument>

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    <periodOfReport>2022-09-01</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001805651</issuerCik>
        <issuerName>MARKETWISE, INC.</issuerName>
        <issuerTradingSymbol>MKTW</issuerTradingSymbol>
    </issuer>

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            <rptOwnerCik>0001871335</rptOwnerCik>
            <rptOwnerName>Stansberry Frank Porter</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1217 ST. PAUL STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BALTIMORE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>21201</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

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    <ownerSignature>
        <signatureName>Frank Porter Stansberry</signatureName>
        <signatureDate>2022-09-06</signatureDate>
    </ownerSignature>
</ownershipDocument>
