X0306 4 2022-09-12 0 0001805387 Cerevel Therapeutics Holdings, Inc. CERE 0001053466 PATRICK DEVAL L C/O CEREVEL THERAPEUTICS HOLDINGS, INC. 222 JACOBS STREET, SUITE 200 CAMBRIDGE MA 02141 1 0 0 0 Common Stock 2022-09-12 4 M 0 47705 12.62 A 47705 D Common Stock 2022-09-12 4 S 0 47705 30.7813 D 0 D Stock Option (Right to Buy) 12.62 2022-09-12 4 M 0 47705 0.00 D 2031-02-01 Common Stock 47705 42685 D These transactions were effected pursuant to a Rule 10b5-1 trading plan dated August 12, 2022 adopted by the Reporting Person. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.29 - $31.11. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. This option shall vest in thirty-six (36) equal monthly installments over three (3) years, with the first installment vested on February 1, 2021. /s/ Mark Bodenrader, as Attorney-in-Fact 2022-09-14