X0306 4 2022-04-13 0 0001805387 Cerevel Therapeutics Holdings, Inc. CERE 0001830363 Renger John C/O CEREVEL THERAPEUTICS HOLDINGS, INC. 222 JACOBS STREET, SUITE 200Z CAMBRIDGE MA 02141 0 1 0 0 Chief Scientific Officer Common Stock 2022-04-13 4 M 0 45000 3.50 A 46980 D Common Stock 2022-04-13 4 S 0 45000 34.6465 D 1980 D Stock Option (Right to Buy) 3.50 2022-04-13 4 M 0 45000 0.00 D 2029-04-02 Common Stock 45000 190875 D These transactions were effected pursuant to a Rule 10b5-1 trading plan dated October 8, 2021 adopted by the Reporting Person. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $34.28 to $34.96 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or to the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. 25% of the shares subject to this option vested and became exercisable on April 8, 2020, with the remainder vesting in thirty-six (36) equal monthly installments thereafter. /s/ Mark Bodenrader, as Attorney-in-Fact 2022-04-15