X0306 4 2022-03-02 0 0001805387 Cerevel Therapeutics Holdings, Inc. CERE 0001830363 Renger John C/O CEREVEL THERAPEUTICS HOLDINGS, INC. 222 JACOBS STREET, SUITE 200 CAMBRIDGE MA 02421 0 1 0 0 Chief Scientific Officer Common Stock 2022-03-02 4 M 0 25000 3.50 A 26980 D Common Stock 2022-03-02 4 S 0 25000 30.00 D 1980 D Stock Option (Right to Buy) 3.50 2022-03-02 4 M 0 25000 0.00 D 2029-04-02 Common Stock 25000 320875 D These transactions were effected pursuant to a Rule 10b5-1 trading plan dated October 8, 2021 adopted by the Reporting Person. 25% of the shares subject to this option vested and became exercisable on April 8, 2020, with the remainder vesting in thirty-six (36) equal monthly installments thereafter. /s/ John Renger 2022-03-04