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    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001805087</cik>
        <entityName>GELESIS HOLDINGS, INC.</entityName>
        <issuerAddress>
            <street1>501 BOYLSTON STREET, SUITE 6102</street1>
            <city>BOSTON</city>
            <stateOrCountry>MA</stateOrCountry>
            <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
            <zipCode>02116</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>617-456-4718</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>CAPSTAR SPECIAL PURPOSE ACQUISITION CORP.</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2020</value>
        </yearOfInc>
    </primaryIssuer>

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                <firstName>Yishai</firstName>
                <lastName>Zohar</lastName>
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                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
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                <relationship>Director</relationship>
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                <firstName>Harry</firstName>
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                <firstName>Alessandro</firstName>
                <lastName>Sannino</lastName>
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            <relatedPersonName>
                <firstName>Elliot</firstName>
                <lastName>Maltz</lastName>
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            <relatedPersonName>
                <firstName>Paul</firstName>
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            <relatedPersonName>
                <firstName>Raju</firstName>
                <lastName>Kucherlapati</lastName>
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            <relatedPersonName>
                <firstName>Dominic</firstName>
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                <street1>GELESIS HOLDINGS, INC.</street1>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alison</firstName>
                <lastName>Bauerlein</lastName>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Clayton</firstName>
                <lastName>Christopher</lastName>
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                <street1>GELESIS HOLDINGS, INC.</street1>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kathryn</firstName>
                <lastName>Cavanaugh</lastName>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2022-08-11</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>50575684</totalOfferingAmount>
            <totalAmountSold>575684</totalAmountSold>
            <totalRemaining>50000000</totalRemaining>
            <clarificationOfResponse>Total Offering Amount represents the aggregate of (i) up to $50,000,000 of common stock and (ii) 355,361 shares of common stock issued as consideration for entering into the Purchase Agreement. See the Issuer's Current Report on Form 8-K filed on 8/12/22.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
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            <findersFees>
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            <clarificationOfResponse></clarificationOfResponse>
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                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>GELESIS HOLDINGS, INC.</issuerName>
                <signatureName>/s/ Elliot Maltz</signatureName>
                <nameOfSigner>Elliot Maltz</nameOfSigner>
                <signatureTitle>Chief Financial Officer and Treasurer</signatureTitle>
                <signatureDate>2022-08-24</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
