<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-02-26</periodOfReport>

    <issuer>
        <issuerCik>0001803696</issuerCik>
        <issuerName>Xperi Holding Corp</issuerName>
        <issuerTradingSymbol>XPER</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001813526</rptOwnerCik>
            <rptOwnerName>Armaly Samir</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O XPERI HOLDING CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>3025 ORCHARD PARKWAY</rptOwnerStreet2>
            <rptOwnerCity>SAN JOSE</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>95134</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President, IP Licensing</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-02-26</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>335479</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>562267</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Reflects accelerated vesting of 335,479 shares subject to performance-based RSUs pursuant to the terms of the Separation Agreement between the Issuer and Reporting Person.</footnote>
        <footnote id="F2">Includes 1,612 shares purchased on August 31, 2021 and 966 shares purchased on February 28, 2022 by the Reporting Person pursuant to the Issuer's Employee Stock Purchase Plan (ESPP).</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Paul E. Davis as Attorney-in-Fact for Samir Armaly</signatureName>
        <signatureDate>2022-03-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
