Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets
Net operating losses	$ 63,702	$ 74,463
Research tax credits	78,340	80,468
Foreign tax credits	29,077	69,637
Expenses not currently deductible	18,823	14,434
Fixed and intangible assets		207
Deferred revenue	8,428	6,385
Capitalized research expenses	38,806	34,963
Lease liability	1,598	1,715
Gross deferred tax assets	238,774	282,272
Valuation allowance	(120,508)	(178,731)
Net deferred tax assets	118,266	103,541
Deferred tax liabilities
Revenue recognition	(4,288)	(1,445)
Operating leases	(1,388)	(1,508)
Acquired intangible assets	(74,075)	(101,679)
Other	(3,237)	(4,076)
Net deferred tax assets	$ 35,278
Net deferred tax liabilities		$ (5,167)