<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001802897</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001776985</issuerCik>
      <issuerName>BioNTech SE</issuerName>
      <secFileNumber>001-39081</secFileNumber>
      <issuerAddress>
        <com:street1>AN DER GOLDGRUBE 12</com:street1>
        <com:city>MAINZ</com:city>
        <com:stateOrCountry>2M</com:stateOrCountry>
        <com:zipCode>55131</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>0049613190840</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ATHOS KG</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Berenberg Capital Markets LLC</name>
        <address>
          <com:street1>1251 Avenue of the Americas, 53rd Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10020</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>15000</noOfUnitsSold>
      <aggregateMarketValue>1830100.50</aggregateMarketValue>
      <noOfUnitsOutstanding>237725735</noOfUnitsOutstanding>
      <approxSaleDate>10/08/2024</approxSaleDate>
      <securitiesExchangeName>NASD</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Ordinary Shares, no par value</securitiesClassTitle>
      <acquiredDate>01/05/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Private placement</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>BioNTech SE</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>15000</amountOfSecuritiesAcquired>
      <paymentDate>01/05/2018</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/13/2024</saleDate>
      <amountOfSecuritiesSold>170000</amountOfSecuritiesSold>
      <grossProceeds>19552584.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/16/2024</saleDate>
      <amountOfSecuritiesSold>590000</amountOfSecuritiesSold>
      <grossProceeds>72893611.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/17/2024</saleDate>
      <amountOfSecuritiesSold>30162</amountOfSecuritiesSold>
      <grossProceeds>3754792.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/18/2024</saleDate>
      <amountOfSecuritiesSold>55605</amountOfSecuritiesSold>
      <grossProceeds>6934500.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/25/2024</saleDate>
      <amountOfSecuritiesSold>37943</amountOfSecuritiesSold>
      <grossProceeds>4495107.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/27/2024</saleDate>
      <amountOfSecuritiesSold>37204</amountOfSecuritiesSold>
      <grossProceeds>4376679.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>09/30/2024</saleDate>
      <amountOfSecuritiesSold>76114</amountOfSecuritiesSold>
      <grossProceeds>8998197.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/01/2024</saleDate>
      <amountOfSecuritiesSold>72086</amountOfSecuritiesSold>
      <grossProceeds>8595657.19</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/02/2024</saleDate>
      <amountOfSecuritiesSold>65200</amountOfSecuritiesSold>
      <grossProceeds>7761192.84</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/03/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>5963585.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/04/2024</saleDate>
      <amountOfSecuritiesSold>14756</amountOfSecuritiesSold>
      <grossProceeds>1812078.12</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>AT Impf GmbH</name>
        <address>
          <com:street1>Rosenheimer Platz 6</com:street1>
          <com:city>Munich</com:city>
          <com:stateOrCountry>2M</com:stateOrCountry>
          <com:zipCode>81669</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>American Depositary Shares representing ordinary shares, no par value per share</securitiesClassTitle>
      <saleDate>10/07/2024</saleDate>
      <amountOfSecuritiesSold>20295</amountOfSecuritiesSold>
      <grossProceeds>2488325.30</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The filing of this Form 144 shall not be construed as an admission that the undersigned is an affiliate of the issuer. All ADS to be sold by AT Impf GmbH.</remarks>
    <noticeSignature>
      <noticeDate>10/08/2024</noticeDate>
      <signature>Berenberg Capital Markets LLC on behalf of /s/ Thomas Maier /s/ Stephan Sperber</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
