X0407 4 2023-06-12 0 0001802768 Royalty Pharma plc RPRX 0001507678 Legorreta Pablo G. C/O ROYALTY PHARMA PLC 110 E. 59TH STREET NEW YORK NY 10022 1 1 1 0 CEO, Chairman of the Board 0 Class A ordinary shares 2023-06-12 4 P 0 45000 32.9988 A 425000 I By Legorreta 2023 SR Trust Class A ordinary shares 2023-06-13 4 P 0 45000 32.7756 A 470000 I By Legorreta 2023 SR Trust Class A ordinary shares 63795 D Class A ordinary shares 460139 I By Legorreta Investments LLC Class A ordinary shares 1284590 I By GST-Exempt Legorreta 2012 Family Trust Class A ordinary shares 41306 I By GST-Exempt Legorreta 2020 Family Trust Class A ordinary shares 10000 I By Child Class A ordinary shares 10000 I By Child Class A ordinary shares 123310 I By IRRA Class A ordinary shares 118500 I By SEP/IRA Class A ordinary shares 1040410 I By Legorreta Children 2002 Trust Class A ordinary shares 6930 I By Spouse Represents shares acquired by the reporting person in open market transactions as part of the reporting person's previously disclosed intention to purchase up to $50 million of the issuer's Class A ordinary shares, as announced in the issuer's press release on March 27, 2023 regarding the issuer's $1.0 billion share repurchase program. The price reported in Column 4 is a weighted average price. The reported securities were purchased in multiple transactions at prices ranging from $32.97 to $33.00. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within such range. The price reported in Column 4 is a weighted average price. The reported securities were purchased in multiple transactions at prices ranging from $32.66 to $32.80. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within such range. /s/ Sean Weisberg, as Attorney-in-Fact for Pablo G. Legorreta 2023-06-13