144 0001677141 XXXXXXXX LIVE 0001802665 HARMONY BIOSCIENCES HOLDINGS, INC. 001-39450 630 W GERMANTOWN PIKE SUITE 215 PLYMOUTH MEETING PA 19462 (484) 539-9800 SANDIP KAPADIA Former Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

7064 233232.09 57892676 06/04/2026 NASDAQ Common 06/04/2026 Exercise of Options Under a Registered Plan Issuer N 7064 06/04/2026 Cash N SANDIP KAPADIA

630 W. Germantown Pike, Suite 215 Plymouth Meeting PA 19462

Common 05/08/2026 45481 1433056.28 06/04/2026 /s/ Sandip Kapadia