SCHEDULE 13G/A 0001821186 XXXXXXXX LIVE 5 Common Stock, $0.00001 par value per share 09/30/2025 0001802665 Harmony Biosciences Holdings, Inc 413197104 630 W. Germantown Pike Suite 215 Plymouth Meeting PA 19462 Rule 13d-1(d) Valor IV Pharma Holdings, LLC DE 0.00 0.00 0.00 0.00 0.00 N 0.0 OO Valor Equity Partners IV L.P. DE 0.00 766836.00 0.00 766836.00 766836.00 N 1.3 PN Valor Equity Partners IV-A L.P. DE 0.00 0.00 0.00 0.00 0.00 N 0.0 PN Valor Equity Partners IV-B L.P. DE 0.00 396651.00 0.00 396651.00 396651.00 N 0.7 PN Valor Equity Associates IV L.P. DE 0.00 1268204.00 0.00 1268204.00 1268204.00 N 2.2 HC Valor Equity Capital IV LLC DE 0.00 1268204.00 0.00 1268204.00 1268204.00 N 2.2 HC Valor Management L.P. DE 29497.00 1268204.00 29497.00 1268204.00 1297701.00 N 2.2 HC Antonio J. Gracias X1 533626.00 1297701.00 533626.00 1297701.00 1831327.00 N 3.2 IN Juan A. Sabater X1 94549.00 1297701.00 94549.00 1297701.00 1392250.00 N 2.4 IN Harmony Biosciences Holdings, Inc 630 W. Germantown Pike, Suite 215, Plymouth Meeting, Pennsylvania, 19462 Each of the following is hereinafter individually referred to as a Reporting Person and collectively as the Reporting Persons. 1) Valor IV Pharma Holdings, LLC 2) Valor Equity Partners IV L.P., 3) Valor Equity Partners IV-A L.P. 4) Valor Equity Partners IV-B L.P. 5) Valor Equity Associates IV L.P. 6) Valor Equity Capital IV LLC 7) Valor Management L.P 8) Antonio J. Gracias 9) Juan A. Sabater The address of each Reporting Person is 320 North Sangamon Street, Suite 1200, Chicago, IL 60607. Each entity Reporting Person is organized under the laws of Delaware. Messrs. Gracias and Sabater are citizens of the United States. See row 9 of the cover pages. See row 11 of the cover pages. See row 5 of the cover pages. See row 6 of the cover page. See row 7 of the cover pages. See row 8 of the cover pages. Valor Management L.P. is the managing member of Valor Equity Capital IV LLC, which is the general partner of Valor Equity Associates IV L.P., which, in turn, is the general partner of each of Valor Equity Partners IV L.P., Valor Equity Partners IV-A L.P. and Valor Equity Partners IV-B L.P., or the "Valor Funds." The Valor Funds are the sole members of Valor IV Pharma Holdings, LLC. By virtue of their positions with Valor Management L.P., each of Messrs. Gracias and Sabater may be deemed to share beneficial ownership over the shares beneficially held by Valor Equity Partners IV L.P., Valor Equity Associates IV L.P. and Valor Management L.P.; however, each disclaims beneficial ownership of such shares for purposes of Sections 13(d) or 13(g) of the Act and the inclusion of such persons in this Schedule 13G shall not be construed as an admission that such persons are, for the purposes of Sections 13(d) or 13(g) of the Act, the beneficial owner of any securities covered by this Schedule 13G. Percent of class is based on (i) the number of shares that may be deemed to be beneficially owned by each Reporting Person as of September 30, 2025 and (ii) the number of shares of common stock outstanding as of October 31, 2025 (57,596,358 shares) as reported by the Issuer in its Form 10-Q filed with the Securities and Exchange Commission on November 4, 2025. N Y Y Y Y Y Y Valor IV Pharma Holdings, LLC /s/ Antonio J. Gracias 11/14/2025 Valor Equity Partners IV L.P. /s/ Antonio J. Gracias 11/14/2025 Valor Equity Partners IV-A L.P. /s/ Antonio J. Gracias 11/14/2025 Valor Equity Partners IV-B L.P. /s/ Antonio J. Gracias 11/14/2025 Valor Equity Associates IV L.P. /s/ Antonio J. Gracias 11/14/2025 Valor Equity Capital IV LLC /s/ Antonio J. Gracias 11/14/2025 Valor Management L.P. /s/ Antonio J. Gracias 11/14/2025 Antonio J. Gracias /s/ Antonio J. Gracias 11/14/2025 Juan A. Sabater /s/ Juan A. Sabater 11/14/2025