Stockholders' Equity - Narrative (Detail) - USD ($)	3 Months Ended		12 Months Ended
	Mar. 31, 2025	Mar. 31, 2024	Dec. 31, 2022	Dec. 31, 2024	Dec. 31, 2021	Dec. 31, 2020
Class of Stock [Line Items]
Common stock, voting rights	one
Total intrinsic value of options exercised	$ 100,000	$ 200,000
Nonvested award, cost not yet recognized	$ 100,000
Stock compensation not yet recognized, vesting period	5 years 7 months 6 days
General and administrative expense
Class of Stock [Line Items]
Share-based payment arrangement expense	$ 1,800,000	2,100,000
Research and development expense
Class of Stock [Line Items]
Share-based payment arrangement expense	$ 500,000	600,000
Stock Plans
Class of Stock [Line Items]
Stock option plan, exercisable period	4 years
Stock Plans | Share-based payment arrangement, nonemployee
Class of Stock [Line Items]
Stock option plan, exercisable period	10 years
Stock Plans | One year from the vesting commencement date
Class of Stock [Line Items]
Stock option plan, vesting percentage	25.00%
Vesting period	1 year
Stock Plans | More than one year from vesting commencement date
Class of Stock [Line Items]
Stock option plan, vesting percentage	2.778%
Employee Stock | Employee Stock Purchase Plan
Class of Stock [Line Items]
Purchase price of common stock	85.00%
Number of shares authorized (in shares)				5,639,944		1,846,710
Evergreen shares reserve feature period	10 years
Percentage of fully diluted shares of common stock	1.00%
Increase in number of shares of authorized common stock (in shares)	3,693,420
Employee Stock | Stock Plans
Class of Stock [Line Items]
Common stock, shares reserved (in shares)	30,752,349			30,040,212
Stock options available for grant (in shares)	5,824,115
Employee Stock | 2021 Equity Incentive Plan
Class of Stock [Line Items]
Number of shares authorized (in shares)					18,467,109
Evergreen shares reserve feature period	10 years
Percentage of fully diluted shares of common stock	5.00%
Maximum percentage of share reserve, outstanding diluted stock	15.00%
Number of additional shares authorized (in shares)	712,137
RSU awards
Class of Stock [Line Items]
Vesting period	1 year 4 months 24 days
Fair value of options vested	$ 400,000	$ 100,000
Release period	60 days
Vested (in shares)	407,548
RSU awards | Stock Plans
Class of Stock [Line Items]
Vesting period	3 years
Requisite service period	3 years
RSU awards | Stock Plans | Tranche one
Class of Stock [Line Items]
Stock option plan, vesting percentage	33.30%
RSU awards | Stock Plans | Tranche two
Class of Stock [Line Items]
Stock option plan, vesting percentage	33.30%
RSU awards | Stock Plans | Tranche three
Class of Stock [Line Items]
Stock option plan, vesting percentage	33.30%
RSU awards | 2021 Equity Incentive Plan
Class of Stock [Line Items]
Stock compensation not yet recognized, vesting period	3 years
Cost not yet recognized, excluding options	$ 12,600,000
Performance-based stock awards
Class of Stock [Line Items]
Share-based payment arrangement expense	$ 8,500,000
Performance-based stock awards | Stock Plans | Minimum
Class of Stock [Line Items]
Stock option plan, vesting percentage	0.00%
Performance-based stock awards | Stock Plans | Maximum
Class of Stock [Line Items]
Stock option plan, vesting percentage	300.00%
Performance-based stock awards | 2021 Equity Incentive Plan
Class of Stock [Line Items]
Vested (in shares)	72,200	27,600
Share-based payment arrangement expense	$ 0	$ 0
Vested and deferred during period (in shares)			391,575