Exhibit 16.1

October 25, 2021
Securities and Exchange Commission 
100 F Street, N.E.
Washington, DC 20549

Ladies and Gentlemen: 

We have read the Form 6-K dated October 25, 2021 of Painreform Ltd. and are in agreement with the statements contained therein.

/s/ Brightman Almagor Zohar & Co.

Certified Public Accountants

A Firm in the Deloitte Global Network

Tel Aviv, Israel
October 25, 2021