X0306 4 2021-04-21 0 0001801777 Applied Molecular Transport Inc. AMTI 0001748622 Bhatt Elizabeth C/O APPLIED MOLECULAR TRANSPORT INC. 1 TOWER PLACE, SUITE 850 SOUTH SAN FRANCISO CA 94080 0 1 0 0 Chief Bus. & Strategy Officer Common Stock 2021-04-21 4 M 0 9000 4.61 A 9000 D Common Stock 2021-04-21 4 S 0 971 39.2992 D 8029 D Common Stock 2021-04-21 4 S 0 5417 40.3819 D 2612 D Common Stock 2021-04-21 4 S 0 2612 41.2133 D 0 D Stock Option (Right to Buy) 4.61 2021-04-21 4 M 0 9000 0.00 D 2020-09-16 2030-03-06 Common Stock 9000 301632 D The price reported in column is a weighted average price. These shares were sold in multiple transactions at prices ranging from $38.86 to $39.80, inclusive. The reporting person undertakes to provide Align Technology, Inc., any security holder of Align Technology, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in column is a weighted average price. These shares were sold in multiple transactions at prices ranging from $39.95 to $40.94, inclusive. The reporting person undertakes to provide Align Technology, Inc., any security holder of Align Technology, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in column is a weighted average price. These shares were sold in multiple transactions at prices ranging from $41.00 to $41.55, inclusive. The reporting person undertakes to provide Align Technology, Inc., any security holder of Align Technology, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. 1/4th of the shares subject to the grant become vested on the Exercisable Date set forth above and 1/48th of the shares subject to the option vest monthly thereafter, provided that the reporting person remains a service provider to the issuer on each such vest date. /s/Brandon Hants Attorney-in-Fact for Elizabeth Bhatt 2021-04-22