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License and collaboration agreements - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended 11 Months Ended 12 Months Ended
Jun. 25, 2020
Jun. 30, 2020
Apr. 30, 2020
Mar. 31, 2021
Mar. 31, 2020
Dec. 31, 2018
Dec. 31, 2019
Dec. 31, 2020
Dec. 19, 2018
Aug. 16, 2018
Jun. 30, 2018
Expense related to milestone payments       $ 0              
KU Leuven [Member]                      
Collaboration expire period 2 years 6 months                    
Emory license agreement [Member] | Emory university [Member]                      
Non-refundable payment   $ 150,000                  
Long term purchase commitment additional obligation to be paid   35,000                  
Research plan funding amount   $ 270,000                  
Research plan expiry period   1 year                  
Long term purchase commitment period description       The research plan terminates one year from the effective date, with the Company having an option to extend for a second year.              
Expense related to milestone payments       $ 80,000              
Payments for royalties       0 $ 0            
Expense or accruals recognized related to royalties       0 0            
Emory license agreement [Member] | Emory university [Member] | Maximum [Member]                      
Aggregate payments                     $ 125,000,000
Emory license agreement [Member] | Series A | Emory university [Member]                      
Debt instrument, conversion price                   $ 9.32  
Luxna license agreement [Member] | Luxna biotech Co Ltd [Member]                      
Expense related to milestone payments       0 0            
Payments for royalties       $ 0 0            
Luxna license agreement [Member] | Luxna biotech Co Ltd [Member] | Maximum [Member]                      
Aggregate payments                 $ 55,500,000    
Katholieke Universiteit Leuven License Agreement [Member] | Katholieke Universiteit Leuven [Member]                      
Non-refundable payment $ 30,000,000                    
Long term purchase commitment period description       Unless terminated earlier by either party, the agreement shall continue until the expiration of the last to expire royalty term, which is the later of the expiration or termination of the last valid patent claim covering the manufacture, use, sale or importation of the licensed product in a particular country or 10 years after the first commercial sale of a licensed product.              
First commercial sale of a licensed product period 10 years                    
Katholieke Universiteit Leuven License Agreement [Member] | Katholieke Universiteit Leuven [Member] | Maximum [Member]                      
Non-refundable payment $ 32,000,000                    
Merck License and Research Collaboration [Member] | Merck [Member]                      
Revenue recognized from collaborative arrangements       $ 910,000 $ 0            
Merck License and Research Collaboration [Member] | Merck [Member] | Maximum [Member]                      
Milestone payments and royalties receivable               $ 458,000,000      
Research and Development [Member] | Emory license agreement [Member] | Emory university [Member]                      
Upfront license fees paid       290,000              
Convertible notes issued for purchasing license       $ 600,000              
Research and Development [Member] | Luxna license agreement [Member] | Luxna biotech Co Ltd [Member]                      
Upfront license fees paid           $ 600,000 $ 600,000        
Non-refundable payment     $ 200,000