Consolidated statements of cash flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities:
Net loss	$ (96,046)	$ (128,332)
Adjustments to reconcile net loss to net cash used in operating activities:
Accretion of discount on short term investments	(159)	86
Amortization of right of use assets	1,369	759
Depreciation expense	2,306	3,019
Stock-based compensation	14,693	13,457
Changes in operating assets and liabilities:
Other assets	5,594	(8,072)
Accounts payable	1,722	(313)
Accrued liabilities	(9,140)	9,742
Operating lease liabilities	(1,819)	(1,404)
Other liabilities	(133)	(245)
Deferred revenue from collaborations	2,502	(4,359)
ROU asset	(278)
Net cash and cash equivalents used in operating activities	(79,389)	(115,662)
Cash flows from investing activities:
Purchases of short-term investments	(104,265)	(2,696)
Purchases of long-term investments		(16,390)
Maturities of short-term investments	78,915	23,000
Purchases of property and equipment	(943)	(892)
Net cash and cash equivalents provided by (used in) investing activities	(26,293)	3,022
Cash flows from financing activities:
Payments on finance lease	(61)	(79)
Payments of deferred offering costs		(875)
Proceeds from ESPP purchase	205
Net cash and cash equivalents provided by financing activities	164	78,677
Net decrease in cash, cash equivalents, and restricted cash	(105,518)	(33,963)
Cash, cash equivalents, and restricted cash, beginning of period	186,980	220,943
Cash, cash equivalents, and restricted cash, end of period	81,462	186,980
Reconciliation to amounts on the consolidated balance sheet:
Cash and cash equivalents	81,347	186,816
Restricted cash	115	164
Cash, cash equivalents, and restricted cash, end of period	81,462	186,980
Supplemental disclosures of noncash financing and investing activities:
Mark to market adjustments for available-for-sale investments	(57)	(109)
Equipment acquired through finance lease		284
Receviable due from arrangement	700
Vesting of early exercised options	209	292
Acquisition of right-of-use asset through operating lease obligation		2,647
PP&E Purchase still in Accounts Payable		15
Change in pension obligation	6	749
Follow-on Offering
Cash flows from financing activities:
Proceeds from issuance of common stock		78,584
Employee Stock
Cash flows from financing activities:
Proceeds from issuance of common stock	$ 20	$ 1,047