CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (55,539)	$ (57,492)
Adjustments to reconcile net loss to net cash used in operating activities:
Accretion of discount on investments	(15)	61
Amortization of right of use assets	626	287
Depreciation expense	1,246	1,511
Stock-based compensation including ESPP	7,786	6,205
Changes in operating assets and liabilities:
Other assets	5,595	(221)
Right of use assets	(278)
Accounts payable	(253)	(1,834)
Accrued liabilities	(12,425)	1,862
Operating lease liabilities	(957)	(626)
Other liabilities		(112)
Deferred revenue from collaborations	8,745	(2,455)
Net cash and cash equivalents used in operating activities	(45,469)	(52,814)
Activities in available-for-sale investments:
Maturities of investments	5,245	10,000
Purchase of short-term investments	(74,776)
Activities in held-to-maturity investments:
Maturities of investments		10,000
Purchases of property and equipment	(849)	(459)
Net cash and cash equivalents (used in) provided by investing activities	(70,380)	19,541
Cash flows from financing activities:
Proceeds from ESPP purchase	111
Payments of deferred offering costs		(99)
Payments on finance lease	(60)	(37)
Proceeds from the exercise of common stock option	11	309
Net cash and cash equivalents provided by financing activities	62	173
Net decrease in cash, cash equivalents, and restricted cash	(115,787)	(33,100)
Cash, cash equivalents, and restricted cash, beginning of period	186,980	220,943
Cash, cash equivalents, and restricted cash, end of period	71,193	187,843
Reconciliation to amounts on the consolidated balance sheet:
Cash and cash equivalents	71,172	187,650
Restricted cash	21	193
Cash, cash equivalents, and restricted cash, end of period	71,193	187,843
Supplemental disclosures of noncash financing and investing activities:
Mark to market adjustment for available-for-sale investments	(402)	(66)
Acquisition of right of use asset through operating lease obligation		184
Vesting of early exercised options	$ 144	126
Change in pension obligation		3
Deferred offering costs in AP and accrued liabilities		$ 637