Stock-based compensation (Tables)

3 Months Ended

Mar. 31, 2022

Summary of Stock Options

Stock option activity during the three months ended March 31, 2022 is as follows:

	Shares subject to options			Weighted- average exercise price		Weighted- average remaining contractual term (years)		Aggregate Intrinsic Value (in thousands)
Outstanding as of January 1, 2022		5,692,514		$	12.07	8.63		$	16,763
Granted		3,642,824		$	3.06
Exercised		(4,966	)	$	2.00
Cancelled		(90,298	)	$	10.94
Outstanding as of March 31, 2022		9,240,074		$	8.53		8.97	$	115
Options vested and expected to vest as of March 31, 2022		9,205,154		$	8.55		8.97	$	115
Options vested and exercisable as of March 31, 2022		2,186,541		$	9.65		8.19	$	83

Summary of Stock Based Compensation Expense Was Allocated

Stock-based compensation expense was allocated as follows for the three months ended March 31, 2022 and 2021 (in thousands):

	Three Months Ended
	March 31,
	2022		2021
Research and development	$	2,001	$	1,709
General and administrative		1,785		1,047
Total	$	3,786	$	2,756

Restricted Stock [Member]

Summary of Stock Options

The following table summarizes the Company’s restricted common stock activity for the three months ended March 31, 2022:

	Number of Awards			Weighted- Average Grant Date Fair Value		Aggregate Fair Value (in thousands)
Issued and unvested as of January 1, 2022		89,054		$	1.30	$	117
Restricted stock awards granted		—
Restricted stock awards vested		(67,816	)	$	1.30	$	(88	)
Issued and unvested as of March 31, 2022		21,238		$	1.30	$	29