Consolidated statements of cash flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Cash flows from operating activities:
Net loss	$ (128,332)	$ (108,543)
Adjustments to reconcile net loss to net cash used in operating activities:
Accretion of discount on short term investments	86	234
Amortization of right of use assets	759	590
Depreciation expense	3,019	2,735
Stock-based compensation	13,457	2,975
Change in fair value of derivative liability		296
Change in fair value of convertible preferred stock liabilities		11,387
Changes in operating assets and liabilities:
Other assets	(8,072)	(4,107)
Accounts payable	(313)	(130)
Accrued liabilities	9,742	9,566
Operating lease liabilities	(1,404)	(1,266)
Other liabilities	(245)
Deferred revenue from collaborations	(4,359)	12,000
Net cash and cash equivalents used in operating activities	(115,662)	(74,263)
Cash flows from investing activities:
Purchases of short-term investments	(2,696)	(32,097)
Purchases of long-term investments	(16,390)	(13,184)
Maturities of short-term investments	23,000	80,100
Purchases of property and equipment	(892)	(2,064)
Net cash and cash equivalents provided by investing activities	3,022	32,755
Cash flows from financing activities:
Payments on finance lease	(79)	(58)
Payments of deferred offering costs	(875)	(4,116)
Proceeds from exercise of warrants for series A redeemable convertible preferred stock		1,125
Proceeds from issuance of redeemable convertible preferred stock Series B-1, net of $37 issuance costs paid		40,000
Payments of series B-1 issuance cost		(405)
Net cash and cash equivalents provided by financing activities	78,677	192,348
Net increase in cash, cash equivalents, and restricted cash	(33,963)	150,840
Cash, cash equivalents, and restricted cash, beginning of period	220,943	70,103
Cash, cash equivalents, and restricted cash, end of period	186,980	220,943
Reconciliation to amounts on the consolidated balance sheet:
Cash and cash equivalents	186,816	220,383
Restricted cash	164	560
Cash, cash equivalents, and restricted cash, end of period	186,980	220,943
Supplemental disclosures of noncash financing and investing activities:
Leasehold improvement directly paid by landlord		79
Liability in connection to the issuance of redeemable convertible preferred stock series B-1		14,560
Mark to market adjustments for available-for-sale investments	(109)	68
Equipment acquired through finance lease	284
Vesting of early exercised options	292	363
Acquisition of right-of-use asset through operating lease obligation	2,647
PP&E Purchase still in Accounts Payable	15	82
Change in pension obligation	749	(141)
Conversion of redeemable convertible preferred stock to common stock in connection with initial public offering		238,522
Change in fair value of derivative liability upon exercise of warrants		757
Follow-on Offering
Cash flows from financing activities:
Proceeds from issuance of common stock	78,584
Employee Stock
Cash flows from financing activities:
Proceeds from issuance of common stock	$ 1,047	260
Initial Public Offering
Cash flows from financing activities:
Proceeds from issuance of common stock		139,500
Over-Allotment Option
Cash flows from financing activities:
Proceeds from issuance of common stock		$ 16,042